A theoretical model has been proposed for acute leukemia developing mechanism (in vivo). The model describes the leukosis dynamics as an increase in the anomalous differentiation cycle energy of tumor blood cells (blasts) at the expense of the lymphocyte and segmented neutrophil cycle energy. The model has been formulated in terms of coupled Van der Pol equations with a time lag. The model solutions are in good agreement with experimental clinical data.
AA Berezin and AV Shmid
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