Journal of Preventive Medicine

Prevention of Zoonotic Crohn's Disease?

Crohn’s disease is a zoonotic immune-mediated disease which is the product of two separate immune system interactions involving Mycobacterium Avium Subspecies Paratuberculosis (MAP). Confronted by MAP infectious challenge, in arresting continued mycobacterium replication, the baby’s inherent immunity may become so stressed that its pro-inflammatory response to MAP becomes fixed within immunological memory . Whenever re-challenged by MAP’s presence in milk-based commercial products, the immune system responds by again unleashing a  immune response against MAP at its site of mucosal attachment rather than exhibiting immunological tolerance. Dealing with MAP as an infectious agent, a baby’s inherent immunity may become so stressed in arresting continued mycobacterium replication that its pro-inflammatory response to MAP becomes fixed within immunological memory

Author(s):

Gilles Monif

Abstract | Full-Text | PDF

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